Add basic explanation of DNA

assets/bibliography.bib

@@ -414,3 +414,96 @@
   year            = 2017,
   pages           = 204
 }
+
+
+
+@Article{CRICK1970,
+  author          = {Crick, Francis},
+  title           = {Central Dogma of Molecular Biology},
+  journal         = {Nature},
+  year            = 1970,
+  month           = {Aug},
+  day             = 01,
+  volume          = 227,
+  number          = 5258,
+  pages           = {561-563},
+  abstract        = {The central dogma of molecular biology deals with the
+                  detailed residue-by-residue transfer of sequential
+                  information. It states that such information cannot be
+                  transferred from protein to either protein or nucleic acid.},
+  issn            = {1476-4687},
+  doi             = {10.1038/227561a0},
+  url             = {https://doi.org/10.1038/227561a0}
+}
+
+@Article{Salk2018,
+  author          = {Salk, Jesse J. and Schmitt, Michael W. and Loeb, Lawrence
+                  A.},
+  title           = {Enhancing the accuracy of next-generation sequencing for
+                  detecting rare and subclonal mutations},
+  journal         = {Nature Reviews Genetics},
+  year            = 2018,
+  month           = {May},
+  day             = 01,
+  volume          = 19,
+  number          = 5,
+  pages           = {269-285},
+  abstract        = {The ability to identify low-frequency genetic variants
+                  among heterogeneous populations of cells or DNA molecules is
+                  important in many fields of basic science, clinical medicine
+                  and other applications, yet current high-throughput DNA
+                  sequencing technologies have an error rate between 1 per 100
+                  and 1 per 1,000 base pairs sequenced, which obscures their
+                  presence below this level.As next-generation sequencing
+                  technologies evolved over the decade, throughput has improved
+                  markedly, but raw accuracy has remained generally unchanged.
+                  Researchers with a need for high accuracy developed data
+                  filtering methods and incremental biochemical improvements
+                  that modestly improve low-frequency variant detection, but
+                  background errors remain limiting in many fields.The most
+                  profoundly impactful means for reducing errors, first
+                  developed approximately 7 years ago, has been the concept of
+                  single-molecule consensus sequencing. This entails redundant
+                  sequencing of multiple copies of a given specific DNA molecule
+                  and discounting of variants that are not present in all or
+                  most of the copies as likely errors.Consensus sequencing can
+                  be achieved by labelling each molecule with a unique molecular
+                  barcode before generating copies, which allows subsequent
+                  comparison of these copies or schemes whereby copies are
+                  physically joined and sequenced together. Because of
+                  trade-offs in cost, time and accuracy, no single method is
+                  optimal for every application, and each method should be
+                  considered on a case-by-case basis.Major applications for
+                  high-accuracy DNA sequencing include non-invasive cancer
+                  diagnostics, cancer screening, early detection of cancer
+                  relapse or impending drug resistance, infectious disease
+                  applications, prenatal diagnostics, forensics and mutagenesis
+                  assessment.Future advances in ultra-high-accuracy sequencing
+                  are likely to be driven by an emerging generation of
+                  single-molecule sequencers, particularly those that allow
+                  independent sequence comparison of both strands of native DNA
+                  duplexes.},
+  issn            = {1471-0064},
+  doi             = {10.1038/nrg.2017.117},
+  url             = {https://doi.org/10.1038/nrg.2017.117}
+}
+
+@book{book:lehninger,
+  title           = {Lehninger-Principles of Biochemistry},
+  author          = {Albert Lehninger, David L. Nelson, Michael M. Cox},
+  publisher       = {W. H. Freeman},
+  isbn            = {9781429224161,1429224169},
+  year            = 2008,
+  edition         = {5th Edition},
+  pages           = 276
+}
+
+@inproceedings{crick1958protein,
+  title           = {On protein synthesis},
+  author          = {Crick, Francis HC},
+  booktitle       = {Symp Soc Exp Biol},
+  volume          = 12,
+  number          = {138-63},
+  pages           = 8,
+  year            = 1958
+}